Specific heparan sulfate structures modulate FGF10-mediated submandibular gland epithelial morphogenesis and differentiation.

@article{Patel2008SpecificHS,
  title={Specific heparan sulfate structures modulate FGF10-mediated submandibular gland epithelial morphogenesis and differentiation.},
  author={Vaishali Patel and Karen M Likar and Simona Zisman-Rozen and Samuel N. Cowherd and Keyonica S Lassiter and Ifat Sher and Edwin A Yates and Jeremy. E. Turnbull and Dina Ron and Matthew P. Hoffman},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 14},
  pages={
          9308-17
        }
}
FGF10, a heparan sulfate (HS)-binding growth factor, is required for branching morphogenesis of mouse submandibular glands (SMGs). HS increases the affinity of FGF10 for FGFR2b, which forms an FGF10.FGFR2b.HS ternary signaling complex, and results in diverse biological outcomes, including proliferation and epithelial morphogenesis. Defining the HS structures involved in specific FGF10-mediated events is critical to understand how HS modulates growth factor signaling in specific developmental… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 47 CITATIONS

References

Publications referenced by this paper.

NUMBER 14 JOURNAL OF BIOLOGICAL CHEMISTRY 9317 by gest on M arch 4, 2015 hp://w w w .jb.org/ D

  • M. Mohammadi, S. K. Olsen, R. Goetz
  • Curr. Opin. Struct. Biol
  • 2005
1 Excerpt

Similar Papers

Loading similar papers…