Specific heat shock proteins protect microtubules during simulated ischemia in cardiac myocytes.

@article{Bluhm1998SpecificHS,
  title={Specific heat shock proteins protect microtubules during simulated ischemia in cardiac myocytes.},
  author={Wolfgang Bluhm and Jody L Martin and Ruben Mestril and Wolfgang H. Dillmann},
  journal={The American journal of physiology},
  year={1998},
  volume={275 6 Pt 2},
  pages={H2243-9}
}
The protective effects of heat shock proteins (HSPs) during myocardial ischemia are now well documented, but little is known about the mechanisms of protection and the specificity of different HSPs. Because cytoskeletal injury plays a crucial role in the pathogenesis of irreversible ischemic damage, we tested whether overexpression of specific HSPs protects the integrity of microtubules during simulated ischemia in rat neonatal cardiac myocytes. Overexpression of specific HSPs was achieved by… CONTINUE READING

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