Specific gap junctions enhance the neuronal vulnerability to brain traumatic injury.

  title={Specific gap junctions enhance the neuronal vulnerability to brain traumatic injury.},
  author={Marina V Frantseva and Larisa Kokarovtseva and Christian C. Naus and Peter L. Carlen and Derrick F Macfabe and Jos{\'e} Luis P{\'e}rez Vel{\'a}zquez},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={22 3},
Traumatic brain injury results in neuronal loss and associated neurological deficits. Although most research on the factors leading to trauma-induced damage focuses on synaptic or ionic mechanisms, the possible role of direct intercellular communication via gap junctions has remained unexplored. Gap junctions connect directly the cytoplasms of coupled cells; hence, they offer a way to propagate stress signals from cell to cell. We investigated the contribution of gap junctional communication… CONTINUE READING


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How to close a gap junction channel. In: Methods in molecular biology, Vol 154: connexin methods and protocols (Bruzzone R, Guiaume C, eds), pp 447–476

  • R Rozental, M Srinivas, DC Spray
  • Totowa, NJ: Humana
  • 2001
Highly Influential
9 Excerpts

Direct evidence for the participation of gap-junction mediated intercellular communication in the transmission of damage signals from alpha-particle irradiated to nonirradiated cells

  • EI Azzam, SM de Toledo, JB Little
  • Proc Natl Acad Sci USA
  • 2001
Highly Influential
3 Excerpts

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