Specific ethanol withdrawal seizures in genetically selected mice.

@article{McSwigan1984SpecificEW,
  title={Specific ethanol withdrawal seizures in genetically selected mice.},
  author={J. McSwigan and J. Crabbe and E. R. Young},
  journal={Life sciences},
  year={1984},
  volume={35 21},
  pages={
          2119-26
        }
}
We are selectively breeding mice prone (WSP) and resistant (WSR) to ethanol withdrawal seizures assessed by handling induced convulsions (HIC). The possibility that differences between the lines in HIC scores are a result of differences in general CNS excitability not specific to ethanol withdrawal was examined. Using treatments which produce generalized seizures (electroconvulsive shock, strychnine, and flurothyl) and gamma amino-butyric acid (GABA) antagonists (picrotoxin, bicuculline, and… Expand
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TLDR
The behavioral results suggest a role for the GABA-chloride channel in the differential ethanol withdrawal seizure behavior of WSR and WSP mice, but this is not due to changes in receptor densities or affinities. Expand
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Mouse lines have been genetically selected to be alcohol Withdrawal Seizure Prone (WSP) or Resistant (WSR), and comparisons for traits related to ethanol sensitivity and tolerance development suggest control in large part by genes different from those influencing withdrawal severity. Expand
Alcohol withdrawal severity in inbred mouse (Mus musculus) strains.
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TLDR
These studies do not provide evidence that sensitivity to the anticonvulsant effect of ethanol is mediated by substantially the same genes as those mediating sensitivity to EtOH's hypnotic effects, however, sensitivity to pentobarbital's anticonVulsant effects may be genetically correlated. Expand
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TLDR
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