Specific ethanol withdrawal seizures in genetically selected mice.

@article{McSwigan1984SpecificEW,
  title={Specific ethanol withdrawal seizures in genetically selected mice.},
  author={John D. McSwigan and J Christopher F Crabbe and Emmett R. Young},
  journal={Life sciences},
  year={1984},
  volume={35 21},
  pages={
          2119-26
        }
}
We are selectively breeding mice prone (WSP) and resistant (WSR) to ethanol withdrawal seizures assessed by handling induced convulsions (HIC). The possibility that differences between the lines in HIC scores are a result of differences in general CNS excitability not specific to ethanol withdrawal was examined. Using treatments which produce generalized seizures (electroconvulsive shock, strychnine, and flurothyl) and gamma amino-butyric acid (GABA) antagonists (picrotoxin, bicuculline, and… CONTINUE READING