Specific enzymatic dephosphorylation of the retinoblastoma protein.

  title={Specific enzymatic dephosphorylation of the retinoblastoma protein.},
  author={John W. Ludlow and C L Glendening and David M. Livingston and J A DeCarprio},
  journal={Molecular and cellular biology},
  volume={13 1},
The retinoblastoma gene product (RB) undergoes cell cycle-dependent phosphorylation and dephosphorylation. Pulse-chase experiments revealed that the change in RB gel electrophoretic migration which occurs near mitosis is due to enzymatic dephosphorylation (J. W. Ludlow, J. Shon, J. M. Pipas, D. M. Livingston, and J. A. DeCaprio, Cell 60:387-396, 1990). To determine the precise timing of RB dephosphorylation and whether a specific phosphatase is active in this process, we have utilized a… CONTINUE READING
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