Specific endocytosis and degradation of naked DNA in the endocardial cells of cod (Gadus morhua L.).

DNA vaccines are administered in the form of plasmid DNA (pDNA) carrying a strong promoter and the gene of interest. In this study we investigated the tissue distribution, cellular uptake and the fate of intravenously (i.v.) and intramuscularly (i.m.) injected pDNA in Atlantic cod (Gadus morhua L.). The anatomical distribution of pDNA was determined using… CONTINUE READING