Specific endocrine and hormonal receptor changes associated with liver regeneration in adult rats.

@article{Leffert1975SpecificEA,
  title={Specific endocrine and hormonal receptor changes associated with liver regeneration in adult rats.},
  author={Hyam L Leffert and Nicholas M. Alexander and G R Faloona and B Rubalcava and Roger Unger},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1975},
  volume={72 10},
  pages={4033-6}
}
Partial removal of the adult rat liver--a procedure that stimulates liver regeneration--causes arterial levels of insulin and thyroxin to fall and glucagon levels to rise. These changes are correlated with the quantity of liver tissue excised and not solely with nonspecific operative manipulations or with blood glucose levels. During regeneration (about 24 hr postoperatively), hepatic plasma membranes become partially resistant to binding glucagon; this change is specific because it is not… CONTINUE READING

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