Specific effects of ethanol on neurite-promoting proteoglycans of neuronal origin

@article{Dow1990SpecificEO,
  title={Specific effects of ethanol on neurite-promoting proteoglycans of neuronal origin},
  author={Kimberly E. Dow and Richard J. Riopelle},
  journal={Brain Research},
  year={1990},
  volume={508},
  pages={40-45}
}
Quantitative analysis of proteoglycan synthesis and release by neurons indicated that of the total incorporation of 35SO4 and [3H]glucosamine into proteoglycan, approximately 75% was chondroitin sulphate while approximately 25% was heparan sulphate. Using a biological assay it has been shown that heparan sulphate proteoglycans (HSPGs) in conditioned medium promote neurite outgrowth from sensory neurons when complexed to a laminin substrate. Culture media conditioned in the presence of ethanol… Expand
Influence of N-linked oligosaccharides on the processing and neurite-promoting activity of proteoglycans released by neurons in vitro
TLDR
Inhibitors of enzymes involved in processing of N-linked oligosaccharides were used to examine biosynthesis and the neurite-promoting activity of proteoglycans produced by and released from dissociated chick embryo spinal cord neurons in vitro to provide further evidence for an autocrine role for heparan sulphate proteoglycan in neurite growth. Expand
Modulation of neurite promoting proteoglycans by neuronal differentiation.
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The role of activity-independent growth and differentiation on the synthesis and release by neurons of neurite growth-promoting proteoglycans is addressed and implications for understanding the role of proteoglycan overexpression and the production of dystrophic neurites in Alzheimer disease are addressed. Expand
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  • W. Wang, K. Dow
  • Biology, Medicine
  • Brain research. Molecular brain research
  • 1997
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These studies suggest that neuronal PGs regulated by activation of EAA receptors mediate neuronal growth responses and increase in neurite growth following glutamate exposure. Expand
Ethanol enhances growth factor-induced neurite formation in PC12 cells
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The present findings suggest that, in some cells, ethanol directly promotes growth factor-mediated neurite formation, which could harm the nervous system by disturbing the balanced development and organization of synapses. Expand
Ethanol enhances neurite outgrowth in primary cultures of rat cerebellar macroneurons.
TLDR
It is indicated that high concentrations of ethanol (150-200 mM) and long periods of exposure (4-7 days) were required to produce toxic effects on neurons and glial cells in this system and that ethanol may have distinct effects on neurite initiation and outgrowth and branching. Expand
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It is shown that glycosaminoglycans added to the culture medium may affect neurite formation in SH‐SY5Y neuroblastoma cells, and that glyCosaminoglycan supplementation to theculture medium lowered the quantity of NGF required to form neurites by PC12 cells. Expand
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TLDR
It is reported that glutamate activation of excitatory amino acid receptors induces the synthesis and release of proteoglycans from fetal hippocampal-astrocytes in dissociated culture and suggests that PKC activation can lead to PG release, but is not necessary for it. Expand
Ethanol Inhibits L1-mediated Neurite Outgrowth in Postnatal Rat Cerebellar Granule Cells*
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One mechanism of ethanol’s toxicity to the developing central nervous system may be the inhibition of L1-mediated neurite outgrowth, which is similar to those of patients with mutations in L1, a neural cell adhesion molecule. Expand
Effects of 4-deoxy-L-threo-pentose, a novel carbohydrate, on neural cell proteoglycan synthesis and function.
TLDR
The data suggest that 4-deoxyxylose inhibits neurite outgrowth by altering the sulphation of the GAGs of heparan sulphate proteoglycans, a novel carbohydrate synthesized by way of reductive dechlorination of a chlorodeoxy sugar. Expand
Core Protein of Chondroitin Sulfate Proteoglycan Promotes Neurite Outgrowth from Cultured Neocortical Neurons
TLDR
Results suggest that CS‐PG stimulates neurite outgrowth from the cultured neurons via its core protein. Expand
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References

SHOWING 1-10 OF 25 REFERENCES
Neuronal proteoglycans: biosynthesis and functional interaction with neurons in vitro
TLDR
The present biosynthetic and functional studies suggest that neurons are one source of HSPGs, which interact with laminin and promote neurite outgrowth that is mediated by a cell surface receptor at or in juxtaposition to the HNK-1 (Leu 7) epitope. Expand
Characterization of a factor that promotes neurite outgrowth: evidence linking activity to a heparan sulfate proteoglycan
TLDR
Rat sympathetic neurons, plated onto extracellular matrix produced by cultured bovine corneal endothelial cells, rapidly extended neurites in the absence of nerve growth factor (NGF), and purification indicated that the active factor may exist as an aggregate containing a heparin sulfate proteoglycan and other molecules. Expand
Immunopurification and characterization of a neuronal heparan sulfate proteoglycan
TLDR
These studies suggest that a HeS proteoglycan synthesized and secreted by neurons and certain accessory cells plays a role in regulating neurite outgrowth. Expand
The heparin‐binding domain of laminin is responsible for its effects on neurite outgrowth and neuronal survival.
TLDR
The survival of cultured chick sympathetic neurons and the outgrowth of neurites were stimulated by the basement membrane protein laminin coated onto polyornithine culture substrates, and the heparin‐binding domain of laminain is responsible for its effects on neurons. Expand
Ethanol neurotoxicity: effects on neurite formation and neurotrophic factor production in vitro.
TLDR
It appears that ethanol alters certain metabolic characteristics of developing neurons that affect survival, attachment, and receptor interactions of sensory neurons with nerve growth factor. Expand
Heparan sulfate proteoglycan of cultured cells: demonstration of a lipid- and a matrix-associated form.
TLDR
Findings indicate an admixture of lipid in this proteoglycan and suggest a location for the molecule in the plasma membrane in heparan sulfate proteoglycans identified in prelabeled cultured cells, including glial cells, endothelial cells and fibroblasts. Expand
A monoclonal antibody against a laminin-heparan sulfate proteoglycan complex perturbs cranial neural crest migration in vivo
TLDR
Embryos ranging from the neural fold stage to the 9-somite stage were injected with INO and subsequently allowed to survive for up to 1 d after injection, indicating that embryos are sensitive for only a limited time during their development and that a laminin-heparan sulfate proteoglycan complex is involved in aspects of neural crest migration in vivo. Expand
A chondroitin sulphate proteoglycan from human cultured glial cells aggregates with hyaluronic acid.
TLDR
It is concluded that the ability to produce large chondroitin sulphate proteoglycan molecules capable of binding to hyaluronic acid is not confined to cartilage cells. Expand
Mapping of domains in human laminin using monoclonal antibodies: localization of the neurite-promoting site
TLDR
The results suggest that the neurite-promoting site may be contained in or close to the 400-kD component of laminin, which is also the site for heparin binding. Expand
The role of glycosaminoglycans in anuran pigment cell migration.
  • R. Tucker
  • Biology, Medicine
  • Journal of embryology and experimental morphology
  • 1986
TLDR
Observed migratory pathways of neural crest-derived pigment cells were examined in two anurans and correlated with the distribution of glycosaminoglycans in the extracellular matrix (ECM) of these pathways suggest that chondroitin sulphate proteoglycan in the subectodermal ECM restricts the migration of pigment cells into the lateral pathway by limiting the amount of space for migration. Expand
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