Specific downregulation of bcl-2 and xIAP by RNAi enhances the effects of chemotherapeutic agents in MCF-7 human breast cancer cells

@article{Lima2004SpecificDO,
  title={Specific downregulation of bcl-2 and xIAP by RNAi enhances the effects of chemotherapeutic agents in MCF-7 human breast cancer cells},
  author={Raquel Tozzo de Lima and L Miguel Martins and Jos{\'e} Eduardo Guimar{\~a}es and Clara Sambade and M Helena Vasconcelos},
  journal={Cancer Gene Therapy},
  year={2004},
  volume={11},
  pages={309-316}
}
  • Raquel Tozzo de Lima, L Miguel Martins, +2 authors M Helena Vasconcelos
  • Published in Cancer Gene Therapy 2004
  • Medicine, Biology
  • Antiapoptotic genes such as bcl-2 or xIAP may be responsible for resistance to apoptosis induced by cytotoxic drugs. The aim of this study was to investigate if downregulation of bcl-2 or xIAP by RNA interference (RNAi) would sensitize MCF-7 cells to etoposide and doxorubicin. FITC-siRNAs uptake was verified by fluorescence microscopy and downregulation of Bcl-2 or XIAP was confirmed by Western Blotting. Both siRNAs reduced the number of viable cells and increased cellular apoptosis. Treatment… CONTINUE READING

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    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 47 REFERENCES

    XIAP, the guardian angel

    VIEW 3 EXCERPTS
    HIGHLY INFLUENTIAL

    Killing the messenger: short RNAs that silence gene expression

    VIEW 1 EXCERPT

    Raf-1 and Bcl-2 induce distinct and common pathways that contribute to breast cancer drug resistance.