Specific down-regulation of an engineered human cyclin D1 promoter by a novel DNA-binding ligand in intact cells.

@article{Laurance2001SpecificDO,
  title={Specific down-regulation of an engineered human cyclin D1 promoter by a novel DNA-binding ligand in intact cells.},
  author={M. E. Laurance and D. Starr and E. Michelotti and E. Cheung and C. Gonz{\'a}lez and A. Tam and J. Deikman and C. Edwards and A. Bardwell},
  journal={Nucleic acids research},
  year={2001},
  volume={29 3},
  pages={
          652-61
        }
}
  • M. E. Laurance, D. Starr, +6 authors A. Bardwell
  • Published 2001
  • Medicine, Biology
  • Nucleic acids research
  • Cyclin D1 is expressed at abnormally high levels in many cancers and has been specifically implicated in the development of breast cancer. In this report we have extensively analyzed the cyclin D1 promoter in a variety of cancer cell lines that overexpress the protein and identified two critical regulatory elements (CREs), a previously identified CRE at -52 and a novel site at -30. In vivo footprinting experiments demonstrated factors binding at both sites. We have used a novel DNA-binding… CONTINUE READING
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