Specific down-regulation of allograft reactivity at the cellular level: graft cells and responder T cells.

@article{MllerRuchholtz1992SpecificDO,
  title={Specific down-regulation of allograft reactivity at the cellular level: graft cells and responder T cells.},
  author={Wolfgang M{\"u}ller-Ruchholtz},
  journal={Immunology letters},
  year={1992},
  volume={32 1},
  pages={1-6}
}
Local immune reactivity in an allograft is largely determined by (1) the immunogenicity of the grafted cells and (2) the presence of recipient allospecific T lymphocytes and, much more importantly, their capacity to react and initiate damage to the graft. Ad (1): It is still widely believed that allograft immunogenicity is sufficiently described by the cell… CONTINUE READING