Specific domains in anterior pharynx-defective 1 determine its intramembrane interactions with nicastrin and presenilin.


γ-Secretase, a multisubunit transmembrane protease comprised of presenilin, nicastrin, presenilin enhancer 2, and anterior pharynx-defective one, participates in the regulated intramembrane proteolysis of Type I membrane proteins including the amyloid precursor protein (APP). Although Aph-1 is thought to play a structural role in the assembly of γ-secretase… (More)
DOI: 10.1016/j.neurobiolaging.2009.12.028

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