Specific docking of apolipoprotein A-I at the cell surface requires a functional ABCA1 transporter.

@article{Chambenoit2001SpecificDO,
  title={Specific docking of apolipoprotein A-I at the cell surface requires a functional ABCA1 transporter.},
  author={Olivier Chambenoit and Yannick Hamon and Didier Marguet and Herv{\'e} Rigneault and Maryvonne Rosseneu and Giovanna Chimini},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 13},
  pages={9955-60}
}
The identification of defects in ABCA1 as the molecular basis of Tangier disease has highlighted its crucial role in the loading with phospholipids and cholesterol of nascent apolipoprotein particles. Indeed the expression of ABCA1 affects apolipoprotein A-I (apoA-I)-mediated removal of lipids from cell membranes, and the possible role of ABCA1 as an apoA-I surface receptor has been recently suggested. In the present study, we have investigated the role of the ABCA1 transporter as an apoA-I… CONTINUE READING
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