Specific distribution of sialic acids in animal tissues as examined by LC-ESI-MS after derivatization with 1,2-diamino-4,5-methylenedioxybenzene.

@article{Morimoto2001SpecificDO,
  title={Specific distribution of sialic acids in animal tissues as examined by LC-ESI-MS after derivatization with 1,2-diamino-4,5-methylenedioxybenzene.},
  author={Naoyuki Morimoto and Miyako Nakano and Mitsuhiro Kinoshita and Atsufumi Kawabata and Mizuki Morita and Yasuo Oda and Ryotaro Kuroda and Kazuaki Kakehi},
  journal={Analytical chemistry},
  year={2001},
  volume={73 22},
  pages={5422-8}
}
Simultaneous analysis of sialic acids has been a challenging target, because sialic acids having N- or O-acetyl, glycolyl, and sulfonic acid ester groups are labile during their release from carbohydrate chains and analytical procedures. In the present paper, we propose a method using high-performance liquid chromatography coupled with eletrospray ionization mass spectrometry (HPLC-ESI-MS). The method was evaluated by applying to the analysis of sialic acids in various tissues, especially… CONTINUE READING

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