Specific disruption of astrocytic Ca2+ signaling pathway in vivo by adeno-associated viral transduction.

@article{Xie2010SpecificDO,
  title={Specific disruption of astrocytic Ca2+ signaling pathway in vivo by adeno-associated viral transduction.},
  author={Yicheng Xie and T Wang and Grace Y Sun and S Ding},
  journal={Neuroscience},
  year={2010},
  volume={170 4},
  pages={992-1003}
}
Astrocytes are the predominant glial-cell type in the CNS and they are known to play an active role in modulating neuronal function. Since many of the same molecules including G-protein coupled receptors (GPCRs) are expressed in both neurons and astrocytes, in vivo pharmacological manipulations to target astrocytes lack specificity. In this study, we investigated the effect of Pleckstrin Homology (PH) domain of Phospholipase C (PLC)-like protein p130 (p130PH) on Ca(2+) signaling in astrocytes… CONTINUE READING
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