Specific detection of the cleavage activity of mycobacterial enzymes using a quantum dot based DNA nanosensor.

Abstract

We present a quantum dot based DNA nanosensor specifically targeting the cleavage step in the reaction cycle of the essential DNA-modifying enzyme, mycobacterial topoisomerase I. The design takes advantages of the unique photophysical properties of quantum dots to generate visible fluorescence recovery upon specific cleavage by mycobacterial topoisomerase I… (More)
DOI: 10.1039/c5nr06326d

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