Specific detection of myeloma plasma cells using anti-idiotypic single chain antibody fragments selected from a phage display library

Abstract

Bone marrow plasma cells constitute the bulk of malignant cells in multiple myeloma patients. B-lymphocytes having immunoglobulin heavy chain gene rearrangements identical to those of the malignant clone (clonally related B-lymphocytes) may function as malignant plasma cell precursors. We and others proposed the use of anti-idiotypic antibodies to isolate… (More)
DOI: 10.1038/sj.leu.2401123

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