• Corpus ID: 6994056

Specific detection of multidrug resistance proteins MRP1, MRP2, MRP3, MRP5, and MDR3 P-glycoprotein with a panel of monoclonal antibodies.

  title={Specific detection of multidrug resistance proteins MRP1, MRP2, MRP3, MRP5, and MDR3 P-glycoprotein with a panel of monoclonal antibodies.},
  author={George L. Scheffer and Marcel Kool and Marc Heijn and Marcel de Haas and A C Pijnenborg and Jan Wijnholds and Ardy van Helvoort and Mariska C de Jong and Jan Hendrik Hooijberg and C A Mol and Mark PG van der Linden and J M de Vree and Paul Van Der Valk and Ronald P.J. Oude Elferink and Piet Borst and Rik J. Scheper},
  journal={Cancer research},
  volume={60 18},
Tumor cells may display a multidrug resistance phenotype by overexpression of ATP binding cassette transporter genes such as multidrug resistance (MDR) 1 P-glycoprotein (P-gp) or the multidrug resistance protein 1 (MRP1). MDR3 P-gp is a close homologue of MDR1 P-gp, but its role in MDR is probably minor and remains to be established. The MRP1 protein belongs to a family of at least six members. Three of these, i.e., MRP1, MRP2, and MRP3, can transport MDR drugs and could be involved in MDR. The… 

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Current knowledge of the structural and transport characteristics of MRP are summarized which suggest that the physiologic functions of this protein could range from a protective role in chemical toxicity and oxidative stress to mediation of inflammatory responses involving cysteinyl leukotrienes.