Specific depletion of preformed IgM natural antibodies by administration of anti-mu monoclonal antibody suppresses hyperacute rejection of pig to baboon renal xenografts.

@article{Dehoux2000SpecificDO,
  title={Specific depletion of preformed IgM natural antibodies by administration of anti-mu monoclonal antibody suppresses hyperacute rejection of pig to baboon renal xenografts.},
  author={J. P. Dehoux and Shingo Hori and St{\'e}phanie Talpe and Herv{\'e} Bazin and Dominique Latinne and Marco P Soares and Pierre Rene Gianello},
  journal={Transplantation},
  year={2000},
  volume={70 6},
  pages={935-46}
}
BACKGROUND The elimination of circulating anti-porcine preformed antibodies is crucial for avoiding hyperacute vascular rejection (HAVR) of primarily vascularized xenograft in discordant pig to baboon model. Previously described methods used for eliminating natural antibodies, however, constantly removed both anti-porcine IgM and IgG antibodies, as well as often complement proteins. To study specifically the role of preformed anti-porcine IgM antibodies, a specific anti-IgM monoclonal antibody… CONTINUE READING