Specific depletion of alloreactive T cells in HLA-identical siblings: a method for separating graft-versus-host and graft-versus-leukaemia reactions.

@article{Mavroudis1998SpecificDO,
  title={Specific depletion of alloreactive T cells in HLA-identical siblings: a method for separating graft-versus-host and graft-versus-leukaemia reactions.},
  author={Damien Mavroudis and Said Dermime and Jeffrey Molldrem and Y. Z. Jiang and Anastasios Raptis and Frits van Rhee and Nancy Fern Hensel and Vicki S Fellowes and George D. Eliopoulos and A John Barrett},
  journal={British journal of haematology},
  year={1998},
  volume={101 3},
  pages={565-70}
}
Accumulating evidence indicates that alloreactive donor T cells confer both graft-versus-host (GVH) and graft-versus-leukaemia (GVL) reactivity following allogeneic bone marrow transplantation. We have developed a method to deplete alloreactive donor T cells with an immunotoxin targeting the alpha chain of the IL-2 receptor. In patients with chronic myeloid leukaemia and their HLA-identical sibling donors, we measured donor helper T-lymphocyte precursor frequencies (HTLPf) against recipient… CONTINUE READING