Specific contribution of the erythropoietin gene 3' enhancer to hepatic erythropoiesis after late embryonic stages.

Abstract

Erythropoietin (Epo) is secreted from the liver and kidney, where Epo production is strictly regulated at the transcriptional level in a hypoxia- and/or anemia-inducible manner. Here, we examined the in vivo function of the enhancer located 3' to the Epo gene (EpoE-3'). Reporter transgenic-mouse analyses revealed that the EpoE-3' enhancer is necessary and… (More)
DOI: 10.1128/MCB.05463-11

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