Specific contribution of estrogen receptors on mitogen-activated protein kinase pathways and vascular cell activation.

@article{Geraldes2003SpecificCO,
  title={Specific contribution of estrogen receptors on mitogen-activated protein kinase pathways and vascular cell activation.},
  author={Pedro Geraldes and Martin G. Sirois and Jean-François Tanguay},
  journal={Circulation research},
  year={2003},
  volume={93 5},
  pages={399-405}
}
Randomized clinical trials have not provided conclusive data that hormone replacement therapy confers cardioprotection against coronary artery disease in postmenopausal women. However, other studies have shown that estrogens can induce beneficial effects on the vasculature. Nevertheless, the specific contribution of estrogen receptors (ERs) alpha and beta on vascular cells is not well characterized. Therefore, we used an antisense gene therapy approach to investigate the contribution of ERalpha… CONTINUE READING