Specific cleavage of the 70-kDa protein component of the U1 small nuclear ribonucleoprotein is a characteristic biochemical feature of apoptotic cell death.

@article{CasciolaRosen1994SpecificCO,
  title={Specific cleavage of the 70-kDa protein component of the U1 small nuclear ribonucleoprotein is a characteristic biochemical feature of apoptotic cell death.},
  author={Livia A. Casciola-Rosen and Douglas K. Miller and Grant J. Anhalt and Antony Rosen},
  journal={The Journal of biological chemistry},
  year={1994},
  volume={269 49},
  pages={30757-60}
}
The U1 small nuclear ribonucleoprotein particle is essential for splicing of precursor mRNA, an activity that depends upon both the RNA and protein components of the U1 particle. One of the U1-specific proteins that is functionally important in this splicing reaction is the 70-kDa protein (U1-70kDa). We report here that U1-70kDa is specifically cleaved in apoptotic cells, resulting in the generation of a 40-kDa fragment. The kinetics of this cleavage coincided with the appearance of cells with… CONTINUE READING
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