Specific cleavage of insulin-like growth factor-binding protein-1 by a novel protease activity

@article{Wang2006SpecificCO,
  title={Specific cleavage of insulin-like growth factor-binding protein-1 by a novel protease activity},
  author={Junke Wang and Jawed Shafqat and Kyla Hall and Marie St{\aa}hlberg and I. -L. Wivall-Helleryd and Karim Bouzakri and Juleen R Zierath and Kerstin E Brismar and Hans J{\"o}rnvall and Moira S. Lewitt},
  journal={Cellular and Molecular Life Sciences CMLS},
  year={2006},
  volume={63},
  pages={2405-2414}
}
Insulin-like growth factor-binding protein-1 (IGFBP-1) is secreted in a highly phosphorylated form that binds IGF-I with high affinity and is resistant to proteolysis. We have purified IGFBP-1-specific protease activity from the urine of an individual with multiple myeloma. This protease efficiently cleaves both phosphorylated and non-phosphorylated IGFBP-1 at Ile130-Ser131, generating fragments that together have higher association and dissociation rates for IGFs compared with intact IGFBP-1… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 37 references

Insulin - like growth factor binding protein proteolysis

R. Clay Bunn, J. L. Fowlkes
Trends Endocrinol . Metab . • 2003

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