Specific changes in the M1 protein during adaptation of influenza virus to mouse

Abstract

The matrix (M) gene of influenza virus has been implicated as a determinant of virulence for mouse brain and lung. Comparison of the M gene sequences of the mouse brain adapted variants A/NWS/33 and A/WSN/33 to their parent, A/WS/33, identified two specific amino acid substitutions in the M1 protein which correlated with virulence for mouse: Ala41 → Val and… (More)
DOI: 10.1007/BF01309872

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Cite this paper

@article{Ward1995SpecificCI, title={Specific changes in the M1 protein during adaptation of influenza virus to mouse}, author={Alan C. Ward}, journal={Archives of Virology}, year={1995}, volume={140}, pages={383-389} }