Specific central nervous system recruitment of HLA-G(+) regulatory T cells in multiple sclerosis.

@article{Huang2009SpecificCN,
  title={Specific central nervous system recruitment of HLA-G(+) regulatory T cells in multiple sclerosis.},
  author={Yu-Hwa Huang and Alla L. Zozulya and Christian Weidenfeller and Imke Metz and Dorothea Buck and Klaus Viktor Toyka and Wolfgang Br{\"u}ck and Heinz Wiendl},
  journal={Annals of neurology},
  year={2009},
  volume={66 2},
  pages={171-83}
}
OBJECTIVE We have recently described a novel population of natural regulatory T cells (T(reg)) that are characterized by the expression of HLA-G and may be found at sites of tissue inflammation (HLA-G(pos) T(reg)). Here we studied the role of these cells in multiple sclerosis (MS), a prototypic autoimmune inflammatory disorder of the central nervous system (CNS). METHODS Sixty-four patients with different types of MS, 9 patients with other neurological diseases, and 20 healthy donors were… CONTINUE READING

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