Specific cellular defects in patients with Fanconi anemia.

  title={Specific cellular defects in patients with Fanconi anemia.},
  author={Rosanna A Weksberg and Manuel Buchwald and P A Sargent and Margaret W. Thompson and Louis Siminovitch},
  journal={Journal of cellular physiology},
  volume={101 2},
Measurements of plating efficiency, accumulation of metaphases and generation times have shown that fibroblast from patients with Fanconi anemia (FA) have decreased probability of completing a further division after successful mitosis. Thus FA cells show decreased growth rates and increased generation times. We have also measured the survival of FA fibroblasts and lymphoblasts after treatment with a variety of mutagens. All FA cells show an increased sensitivity to drugs such as MMC and… CONTINUE READING
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