Specific cell tropism and neutralization of human parechovirus types 1 and 3: implications for pathogenesis and therapy development.

@article{Westerhuis2012SpecificCT,
  title={Specific cell tropism and neutralization of human parechovirus types 1 and 3: implications for pathogenesis and therapy development.},
  author={Brenda M. Westerhuis and Gerrit Koen and Joanne G Wildenbeest and Dasja Pajkrt and Menno D. T. de Jong and Kimberley S M Benschop and Katja C. Wolthers},
  journal={The Journal of general virology},
  year={2012},
  volume={93 Pt 11},
  pages={2363-70}
}
Human parechoviruses (HPeVs) are picornaviruses frequently infecting humans. While HPeV1 is associated with mild disease, HPeV3 is the cause of neonatal sepsis and meningitis. To test whether in vitro replication kinetics of HPeV1 and HPeV3 could be related to pathogenicity, HPeV1 and HPeV3 strains isolated from patients were cultured on cell lines of gastrointestinal, respiratory and neural origin, and replication kinetics were measured by real-time PCR. No relationship was found between… CONTINUE READING