Specific cathepsin B inhibitor is cell-permeable and activates presentation of TTC in primary human dendritic cells.

@article{Reich2009SpecificCB,
  title={Specific cathepsin B inhibitor is cell-permeable and activates presentation of TTC in primary human dendritic cells.},
  author={Michael P Reich and Ewa Wieczerzak and Elżbieta Jankowska and David Palesch and B O Boehm and Timo Burster},
  journal={Immunology letters},
  year={2009},
  volume={123 2},
  pages={155-9}
}
Cathepsins of the cysteine, aspartyl, and serine classes are involved in antigen processing in the class II major histocompatibility complex (MHC) loading compartment. Investigation of these proteases in living cells is difficult to perform due to the lack of highly specific cell-permeable inhibitors. Recently, a highly selective cathepsin B (CatB) inhibitor, Z-Arg-Leu-Arg-alpha-aza-glycyl-Ile-Val-OMe (ZRLR), was described. We found that ZRLR is cell-permeable and specifically inhibits CatB, in… CONTINUE READING