Specific calpain inhibition by calpastatin prevents tauopathy and neurodegeneration and restores normal lifespan in tau P301L mice.

Abstract

Tau pathogenicity in Alzheimer's disease and other tauopathies is thought to involve the generation of hyperphosphorylated, truncated, and oligomeric tau species with enhanced neurotoxicity, although the generative mechanisms and the implications for disease therapy are not well understood. Here, we report a striking rescue from mutant tau toxicity in the… (More)
DOI: 10.1523/JNEUROSCI.1132-14.2014

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@article{Rao2014SpecificCI, title={Specific calpain inhibition by calpastatin prevents tauopathy and neurodegeneration and restores normal lifespan in tau P301L mice.}, author={M. V. Madhava Rao and Mary Kate McBrayer and Jabbar Campbell and Asok Kumar and Audrey Hashim and Henry W. Sershen and Philip H Stavrides and Masuo Ohno and Michael James Hutton and Ralph A. Nixon}, journal={The Journal of neuroscience : the official journal of the Society for Neuroscience}, year={2014}, volume={34 28}, pages={9222-34} }