Specific calcium antagonist binding sites in brain.

@article{Marangos1982SpecificCA,
  title={Specific calcium antagonist binding sites in brain.},
  author={Paul J. Marangos and Jitendra Patel and C Miller and Andrea M. Martino},
  journal={Life sciences},
  year={1982},
  volume={31 15},
  pages={
          1575-85
        }
}
The binding of the calcium antagonist [3H] nitrendipine ([3H] NDP) to brain and heart is described and the brain site is characterized. The binding is saturable, specific and of very high affinity with KD values of 0.16 nM in brain and 0.21 nM in heart. Our kinetic results are similar to those recently reported by two other groups (1, 2), indicating a saturable, high affinity binding site in brain. In brain the binding sites are enriched in crude nuclear and synaptosomal fractions. The highest… Expand
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Differential sensitivity of [3H]nitrendipine binding to cations of toxicological interest in various rat brain areas.
[3H]Nitrendipine ([3H]NTP) is a radiolabelled calcium antagonist which can be used to study neuronal calcium (Ca2+) channels. The interaction of Mn2+, Zn2+, Pb2+ and La3+ on [3H]NTP binding wasExpand
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