Specific blockade of the ERK pathway inhibits the invasiveness of tumor cells: down-regulation of matrix metalloproteinase-3/-9/-14 and CD44.

@article{Tanimura2003SpecificBO,
  title={Specific blockade of the ERK pathway inhibits the invasiveness of tumor cells: down-regulation of matrix metalloproteinase-3/-9/-14 and CD44.},
  author={Susumu Tanimura and Keita Asato and Shuh-hei Fujishiro and Michiaki Kohno},
  journal={Biochemical and biophysical research communications},
  year={2003},
  volume={304 4},
  pages={
          801-6
        }
}
Elevated expression of matrix metalloproteinases (MMPs) is associated with increased metastatic potential in many tumor cells. As activation of the ERK pathway has been linked to the expression of MMP-9, we examined a possible correlation between ERK activation, MMP-9 expression, and invasive phenotype in human tumor cells. Activation state of the ERK pathway in tumor cells was well correlated with the invasive phenotype, which was determined by the ability of cells to invade through… CONTINUE READING

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