Specific blockade of morphine- and cocaine-induced reinforcing effects in conditioned place preference by nitrous oxide in mice

  title={Specific blockade of morphine- and cocaine-induced reinforcing effects in conditioned place preference by nitrous oxide in mice},
  author={Nadia Benturquia and St{\'e}phanie Le Guen and Corine Canestrelli and Vincent Lagente and Gabriela Apiou and B. P. Roques and Florence Noble},

The effects of xenon and nitrous oxide gases on alcohol relapse.

Exposure to Xe during the last 24 hours of abstinence produced a trend toward reduced ethanol intake during the first alcohol re-exposure days, and Xe gas exposure significantly decreased the cue-induced reinstatement of alcohol-seeking behavior.

Ketamine blocks the correlation between morphine-induced conditioned place preference and anxiety-like behaviors in mice

The results suggest that morphine-induced CPP may be driven by negative reinforcement, which can be prevented by acute ketamine administration, and this suggests that opioid-seeking behaviors in mice were correlated with the negative affect of anxiety.

Asymmetric Involvement of Central and the Peripheral NMDA Glutamate Receptors in the Expression of Withdrawal Syndrome in Morphine-Dependent Mice

The role of N- methyl-D aspartic acid (NMDA) glutamate receptor on naloxone-induced withdrawal syndrome in morphine-conditioned mice is investigated and injection of memantine significantly attenuated n aloxone precipitated jumping count, jumping height and fecal material output in morphine dependent mice.

Ketamine Blocks Morphine-Induced Conditioned Place Preference and Anxiety-Like Behaviors in Mice

The results suggest that the ketamine-induced block of morphine CPP may not be attributed solely to alleviating negative affective states, but potentially through impaired memory of morphine-context associations.

Drug-Induced Conditioned Place Preference and Its Practical Use in Substance Use Disorder Research

The case is supported to support the case that the CPP method is specifically advantageous for studying the role of a form of Pavlovian learning that associates drug use with the surrounding environment.

Endogenous opiates and behavior: 2007

Hippocampal Long-Term Potentiation Is Disrupted during Expression and Extinction But Is Restored after Reinstatement of Morphine Place Preference

Morphine CPP is associated with increased basal synaptic transmission, impaired hippocampal long-term potentiation (LTP), and increased synaptic expression of the NR1 and NR2b NMDAR subunits, and it is found that reinstatement of morphine CPP was prevented by the selective blockade of theNR2b subunit in the hippocampus.



Nitrous oxide or halothane, or both, fail to suppress c-fos expression in rat spinal cord dorsal horn neurones after subcutaneous formalin.

It is suggested that measuring the genetic product of c-fos proto-oncogene is a useful adjunct to pharmacological tests whenever behavioural hyperalgesia is questionable or unobtainable and supports the previous hypothesis that inhalation anaesthesia lacks pre-emptive analgesic action.

Nitrous oxide generalizes to a discriminative stimulus produced by ethylketocyclazocine but not morphine.

Nitrous oxide exhibits some pharmacological properties similar to those of morphine, for example, naloxone reversible analgesia, yet it has other properties such as subjective effects that are dissimilar from morphine.

Persistent Disruption of an Established Morphine Conditioned Place Preference

It was found that an established morphine conditioned place preference (mCPP) was persistently disrupted if protein synthesis was blocked by either anisomycin or cycloheximide after the representation of a conditioning session.

Effects of Gaseous Anesthetics Nitrous Oxide and Xenon on Ligand-gated Ion Channels: Comparison with Isoflurane and Ethanol

The results suggest that NMDA receptors and nACh receptors composed of &bgr;2 subunits are likely targets for nitrous oxide and xenon, which are distinct from that of isoflurane or ethanol.