Specific binding sites for oestrogen at the outer surfaces of isolated endometrial cells

@article{Pietras1977SpecificBS,
  title={Specific binding sites for oestrogen at the outer surfaces of isolated endometrial cells},
  author={Richard J Pietras and Clara M. Szego},
  journal={Nature},
  year={1977},
  volume={265},
  pages={69-72}
}
OESTROGENS are more readily accumulated and retained in responsive cells than in cells that are not their targets1. Cytoplasmic macromolecules2 which specifically interact with oestradiol and other steroid hormones seem to mediate transfer of the agonist to the nuclear chromatin, where the complex is believed to promote expression of the phenotypic effects3… CONTINUE READING