Specific binding of insulin-like growth factors 1 and 2 to the type 1 and type 2 receptors respectively.

@article{Ballard1988SpecificBO,
  title={Specific binding of insulin-like growth factors 1 and 2 to the type 1 and type 2 receptors respectively.},
  author={Francis John Ballard and Monique Deidre Ross and Faye M. Upton and Geoffrey Leonard Francis},
  journal={The Biochemical journal},
  year={1988},
  volume={249 3},
  pages={
          721-6
        }
}
1. Competitive binding and receptor cross-linking experiments have been used to examine the receptor-ligand interactions between three bovine insulin-like growth factors (IGF) and monolayer cultures of myoblasts and fibroblasts. 2. Labelled IGF-2 bound predominantly to the type 2 receptor with negligible label cross-linked to the type 1 receptor, notwithstanding the ability of IGF-2 to compete effectively for the binding of IGF-1 to the type 1 receptor. Approx. 100-fold higher concentrations of… CONTINUE READING
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