Specific binding of endocrine transforming growth factor-beta 1 to vascular endothelium.

@article{Dickson1995SpecificBO,
  title={Specific binding of endocrine transforming growth factor-beta 1 to vascular endothelium.},
  author={Kathleen M. Dickson and Annie Philip and Hershey Warshawsky and Maureen D. O'Connor-McCourt and John J. M. Bergeron},
  journal={The Journal of clinical investigation},
  year={1995},
  volume={95 6},
  pages={2539-54}
}
The presentation of recombinant biologically active 125I-TGF-beta 1 via the bloodstream to potential target cells in mice and rats was evaluated by quantitative light and electron microscope radioautography. Specificity was evaluated by in vivo competition with excess unlabeled TGF-beta 1, and integrity of the ligand at the binding site was demonstrated by trichloroacetic acid precipitation after extraction from tissues. The distribution of radiolabel at 2.5, 15, 30, 45, and 60 min after 125I… CONTINUE READING

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