Specific binding of basic fibroblast growth factor to basement membrane-like structures and to purified heparan sulfate proteoglycan of the EHS tumor.

@article{Vigny1988SpecificBO,
  title={Specific binding of basic fibroblast growth factor to basement membrane-like structures and to purified heparan sulfate proteoglycan of the EHS tumor.},
  author={Marc Vigny and Marie-Paule Ollier-Hartmann and Martin J F Lavigne and Nicole A Fayein and Jean Claude Jeanny and Maryvonne Laurent and Yves Courtois},
  journal={Journal of cellular physiology},
  year={1988},
  volume={137 2},
  pages={321-8}
}
The binding of iodinated basic fibroblast growth factor (bFGF) to low-density heparan sulfate proteoglycan purified from the Engelbreth Holm Swarm (EHS) sarcoma was investigated using different techniques. The tumor clearly contained bFGF, the level being comparable to that found in other tissues such as human or bovine brain. 125I bFGF strongly bound to the basement membrane-like matrix of EHS frozen sections as revealed by autoradiography. Iodinated bFGF bound to purified heparan sulfate… CONTINUE READING