Specific binding of a HeLa cell nuclear protein to RNA sequences in the human immunodeficiency virus transactivating region.

@article{Gaynor1989SpecificBO,
  title={Specific binding of a HeLa cell nuclear protein to RNA sequences in the human immunodeficiency virus transactivating region.},
  author={Richard B. Gaynor and E Soultanakis and Mikinori Kuwabara and Joseph Anthony Garcia and David S. Sigman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1989},
  volume={86 13},
  pages={4858-62}
}
The transactivator protein, tat, encoded by the human immunodeficiency virus is a key regulator of viral transcription. Activation by the tat protein requires sequences downstream of the transcription initiation site called the transactivating region (TAR). RNA derived from the TAR is capable of forming a stable stem-loop structure and the maintenance of both the stem structure and the loop sequences located between +19 and +44 is required for complete in vivo activation by tat. Gel retardation… CONTINUE READING

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