Specific binding of [3H]pyrilamine to histamine H1 receptors in guinea pig brain in vivo: determination of binding parameters by a kinetic four-compartment model.

@article{Yanai1990SpecificBO,
  title={Specific binding of [3H]pyrilamine to histamine H1 receptors in guinea pig brain in vivo: determination of binding parameters by a kinetic four-compartment model.},
  author={Kazuhiko Yanai and Nobuhiro Yagi and Takehiko Watanabe and Masatoshi Itoh and Kiichi Ishiwata and Tatsuo Ido and Taiju Matsuzawa},
  journal={Journal of neurochemistry},
  year={1990},
  volume={55 2},
  pages={409-20}
}
The binding of [3H]pyrilamine, a selective ligand of histamine H1 receptors, to guinea pig brain in vivo was compared with its binding to a brain homogenate. The pharmacological properties (regional distribution, saturability, and stereoselectivity) of the [3H]pyrilamine binding in vivo were similar to those of the in vitro binding to brain homogenate. A dynamic four-compartment model was proposed for the analysis of the kinetics of [3H]pyrilamine binding in vivo. The receptor constants in vivo… CONTINUE READING

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