Specific beta1-adrenergic receptor silencing with small interfering RNA lowers high blood pressure and improves cardiac function in myocardial ischemia.

@article{Arnold2007SpecificBR,
  title={Specific beta1-adrenergic receptor silencing with small interfering RNA lowers high blood pressure and improves cardiac function in myocardial ischemia.},
  author={Anne-Sophie Arnold and Yao Liang Tang and Keping Qian and Leping Shen and Valery Valencia and Michael Ian Phillips and Yuan Clare Zhang},
  journal={Journal of hypertension},
  year={2007},
  volume={25 1},
  pages={197-205}
}
OBJECTIVES Beta-blockers are widely used and effective for treating hypertension, acute myocardial infarction (MI) and heart failure, but they present side-effects mainly due to antagonism of beta2-adrenergic receptor (AR). Currently available beta-blockers are at best selective but not specific for beta1 or beta2-AR. METHODS To specifically inhibit the expression of the beta1-AR, we developed a small interfering RNA (siRNA) targeted to beta1-AR. Three different sequences of beta1 siRNA were… CONTINUE READING