Specific association of thiamine-coated gadolinium nanoparticles with human breast cancer cells expressing thiamine transporters.

  title={Specific association of thiamine-coated gadolinium nanoparticles with human breast cancer cells expressing thiamine transporters.},
  author={Moses O. Oyewumi and Shuqiang Liu and Jeffrey A Moscow and Russell J. Mumper},
  journal={Bioconjugate chemistry},
  volume={14 2},
Thiamine (vitamin B(1)) was investigated as a tumor-specific ligand for gadolinium nanoparticles. Solid nanoparticles containing gadolinium hexanedione (1.5 mg/mL) were engineered from oil-in-water microemulsion templates and coated with thiamine ligands. Thiamine ligands were synthesized by conjugating thiamine to either distearoylphosphatidylethanolamine (DSPE) or fluorescein via a poly(ethylene glycol) (PEG) spacer (Mw 3350). The efficiency of thiamine ligand attachment to nanoparticles was… 
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