Specific association of a CLEC16A/KIAA0350 polymorphism with NOD2/CARD15− Crohn's disease patients

@article{Mrquez2009SpecificAO,
  title={Specific association of a CLEC16A/KIAA0350 polymorphism with NOD2/CARD15− Crohn's disease patients},
  author={Ana Citlali M{\'a}rquez and Jezabel Varad{\'e} and Gema Robledo and Alfonso Mo{\~n}ux Mart{\'i}nez and Juan Lu{\'i}s Mendoza and Carlos Taxonera and Miguel Fern{\'a}ndez-Arquero and Manuel D{\'i}az-Rubio and Mar{\'i}a Rosario G{\'o}mez-Garc{\'i}a and Miguel {\'A}ngel L{\'o}pez-Nevot and Emilio G{\'o}mez de la Concha and Javier Mart{\'i}n and Elena Urcelay},
  journal={European Journal of Human Genetics},
  year={2009},
  volume={17},
  pages={1304-1308}
}
Independent genome-wide association studies highlighted the function of CLEC16A/KIAA0350 polymorphisms modifying the risk to either multiple sclerosis (rs6498169) or type 1 diabetes (rs2903692). This C-type lectin gene maps to a linkage disequilibrium block at 16p13 and a functional role of this gene could be envisaged for other immune-related conditions, such as inflammatory bowel disease (IBD). The present study, aimed at investigating the association of those two polymorphisms with IBD… CONTINUE READING

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Genome - wide association study of 14 000 cases of seven common diseases and 3000 shared controls

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