Specific assembly pathway of sarcoglycans is dependent on beta- and delta-sarcoglycan.

@article{Shi2004SpecificAP,
  title={Specific assembly pathway of sarcoglycans is dependent on beta- and delta-sarcoglycan.},
  author={Weixing Shi and Zaili Chen and Jodi Schottenfeld and Richard C Stahl and Louis M. Kunkel and Yiu-mo Michael Chan},
  journal={Muscle & nerve},
  year={2004},
  volume={29 3},
  pages={409-19}
}
Mutations in sarcoglycans (SG) have been reported to cause autosomal-recessive limb-girdle muscular dystrophy (LGMD) and dilated cardiomyopathy. In skeletal and cardiac muscle, sarcoglycans exist as a complex of four transmembrane proteins (alpha-, beta-, gamma-, and delta-SG). In this study, the assembly of the sarcoglycan complex was examined in a heterologous expression system. Our results demonstrated that the assembly process occurs as a discrete stepwise process. We found that beta-SG… CONTINUE READING