Specific anosmia to 1-pyrroline: The spermous primary odor

  title={Specific anosmia to 1-pyrroline: The spermous primary odor},
  author={John E. Amoore and L. Janet Forrester and Ron G. Buttery},
  journal={Journal of Chemical Ecology},
About 20% of human subjects are specifically anosmic to the odor of the heterocyclic Schiff's base 1-pyrroline. Odor threshold measurements on 33 nitrogenous bases were made with panels of specific anosmics and normal observers. The anosmia proved to be very selective, and was encountered only with 1-pyrroline and its homolog 1-piperideine. The odor of 1-pyrroline resembles very closely that of human semen, and possibly represents a vestigial pheromone. It is suggested that this specific… 

Specific anosmia to trimethylamine: The fishy primary odor

About 7% of human subjects are specifically anosmic to the odor of trimethylamine, suggested that this specific anosmia corresponds with the absence of a new olfactory primary, the “fishy” odor.

On the chemistry of 1-pyrroline in solution and in the gas phase

The results indicate that in solution the volatility of the monomer species is significantly higher than that of the trimer species, and 1-pyrroline is evaporated mainly in its monomer state.

Mexican Fruit Fly Attractants: Effects of 1-Pyrroline and Other Amines on Attractiveness of a Mixture of Ammonia, Methylamine, and Putrescine

Several amines were tested alone and in combination with AMPu, an attractant mixture containing ammonium bicarbonate or ammonium carbonate, methylamine hydrochloride, and putrescine, for

Birth of a new breed of supertaster.

  • D. Reed
  • Psychology
    Chemical senses
  • 2008
It is reported that a subject’s response to the bitter chemical 6-n-propylthiouracil (PROP) is less predictive of overall taste intensity ratings than ratings of sucrose, sodium chloride, and citric acid.

Early release of 1-pyrroline by Pseudomonas aeruginosa cultures discovered using ambient corona discharge ionization mass spectrometry

The results indicate the high suitability of volatile 1-pyrroline for the early and reliable diagnosis of Pseudomonas infections using commonly available MS instrumentation.

Odorant–Receptor Interactions and Odor Percept: A Chemical Perspective

There is no simple, direct correlation between a molecule's ability to activate this receptor and the odor impression elicited in the brain, and simplistic ‘lock and key’ models of olfaction based on a concept of odor‐quality‐tuned receptors are inadequate, irrespective of the nature of the lock–key interaction.



1‐Pyrroline: The Odor Component of Strecker‐Degraded Proline and Ornithine

SUMMARY The odor component of proline and ornithine degraded by periodate, isatin, or ninhydrin was identified as 1-pyrroline by means of gas chromatography on three columns, mass spectra, and

Measurement of Specific Anosmia

The objective of this work was to measure the quantitative deficiency of the specific anosmics, in comparison with normal Ss with respect to each odorant, for the definition of what is believed to be one of the “primary odors” of the sense of smell, the "sweaty" primary epitomized by isovaleric acid.

Specific Anosmia: a Clue to the Olfactory Code

The fact that some people cannot detect the odour of isobutyric acid even though their sense of smell may be otherwise complete suggests that this substance, or a substance with molecules which are similar in size, shape and functional group, may represent a primary odour.


This article attempts to tie together some facts regarding the role of spermidine and spermine, and their biosynthetic precursor putrescine, in a number of disparate processes related to reproduction in mammals and suggests some thoughts as to their possible functional significance.

Odour-Blindness to Musk: Simple Recessive Inheritance

THREE types of odour-blindness or specific anosmia have been studied, but genetical evidence so far obtained is tentative or inconsistent1. The rare anosmia to the n-butylmercaptan of skunk2, and

Odour-Blindness to Musk: Simple Recessive Inheritance

Specific anosmia in humans to two substances, iso-valeric acid and a musk, and a difference of incidence in both anosmias between Black and Caucasian subjects is found.

Beitrag zur Chemic des Sputums

  • Z. Physiol. Chem. 156"144-152.
  • 1926