Specific and redundant functions of the paralogous Hoxa-9 and Hoxd-9 genes in forelimb and axial skeleton patterning.

@article{FromentalRamain1996SpecificAR,
  title={Specific and redundant functions of the paralogous Hoxa-9 and Hoxd-9 genes in forelimb and axial skeleton patterning.},
  author={Catherine Fromental-Ramain and Xavier M Warot and Sai Kiran Lakkaraju and Beno{\^i}t Favier and Herbert Haack and C Birling and Andr{\'e}e Di{\'e}rich and P Doll e and Pierre Chambon},
  journal={Development},
  year={1996},
  volume={122 2},
  pages={461-72}
}
Using gene targeting, we have produced mice with a disruption of Hoxa-9 or Hoxd-9, two paralogous Abdominal B-related genes. During embryogenesis, these genes are expressed in limb buds and along the vertebral axis with anterior expression boundaries at the level of prevertebra #20 for Hoxa-9 and #23 for Hoxd-9. Skeletal analysis revealed homeotic transformations corresponding to anteriorisations of vertebrae #21 to #25 (L1 to L5) in the lumbar region of Hoxa-9-/- mutants; vertebrae #23 to #25… CONTINUE READING
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