Specific and pleiotropic patterns of mRNA regulation by ArcZ, a conserved, Hfq-dependent small RNA.

@article{Papenfort2009SpecificAP,
  title={Specific and pleiotropic patterns of mRNA regulation by ArcZ, a conserved, Hfq-dependent small RNA.},
  author={Kai Papenfort and Nelly Said and Tim Welsink and Sacha Lucchini and Jay C. D. Hinton and J{\"o}rg Vogel},
  journal={Molecular microbiology},
  year={2009},
  volume={74 1},
  pages={
          139-158
        }
}
The small RNA, ArcZ (previously RyhA/SraH), was discovered in several genome-wide screens in Escherichia coli and Salmonella. Its high degree of genomic conservation, its frequent recovery by shotgun sequencing, and its association with the RNA chaperone, Hfq, identified ArcZ as an abundant enterobacterial 'core' small RNA, yet its function remained unknown. Here, we report that ArcZ acts as a post-transcriptional regulator in Salmonella, repressing the mRNAs of the widely distributed sdaCB… CONTINUE READING

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