Specific amino acid deficiency alters the expression of genes in human melanoma and other tumor cell lines.


This study determined the effect of tyrosine (Tyr) and phenylalanine (Phe) deprivation on protein expression and phosphorylation of mitogen-activated protein kinase kinase 4 (MKK4)/stress-activated protein/Erk kinase (SEK1), a metastasis suppressor gene. Differential display and suppressive subtractive hybridization techniques identified genes modulated by… (More)
DOI: 10.1093/jn/131.11.3047S


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