Specific ablation of the transcription factor CREB in sympathetic neurons surprisingly protects against developmentally regulated apoptosis.

@article{Parlato2007SpecificAO,
  title={Specific ablation of the transcription factor CREB in sympathetic neurons surprisingly protects against developmentally regulated apoptosis.},
  author={Rosanna Parlato and Christiane Otto and Yvonne Begus and Stephanie C. Stotz and G. Sch{\"u}tz},
  journal={Development},
  year={2007},
  volume={134 9},
  pages={1663-70}
}
The cyclic-AMP response element-binding (CREB) protein family of transcription factors plays a crucial role in supporting the survival of neurons. However, a cell-autonomous role has not been addressed in vivo. To investigate the cell-specific role of CREB, we used as a model developing sympathetic neurons, whose survival in vitro is dependent on CREB activity. We generated mice lacking CREB in noradrenergic (NA) and adrenergic neurons and compared them with the phenotype of the germline CREB… CONTINUE READING