Specific Unsaturated Fatty Acids Enforce the Transdifferentiation of Human Cancer Cells toward Adipocyte-like Cells

@article{RuizVela2011SpecificUF,
  title={Specific Unsaturated Fatty Acids Enforce the Transdifferentiation of Human Cancer Cells toward Adipocyte-like Cells},
  author={Antonio Ruiz-Vela and Crist{\'o}bal Aguilar-Gallardo and Ana M. Mart{\'i}nez-Arroyo and Mario Soriano-Navarro and Ver{\'o}nica Ruiz and Carlos Sim{\'o}n},
  journal={Stem Cell Reviews and Reports},
  year={2011},
  volume={7},
  pages={898-909}
}
Differentiation therapy pursues the discovery of novel molecules to transform cancer progression into less aggressive phenotypes by mechanisms involving enforced cell transdifferentiation. In this study, we examined the identification of transdifferentiating adipogenic programs in human cancer cell lines (HCCLs). Our findings showed that specific unsatturated fatty acids, such as palmitoleic, oleic and linoleic acids, trigger remarkable phenotypic modifications in a large number of human cancer… CONTINUE READING